STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_3848Selenocysteine lyase. (547 aa)    
Predicted Functional Partners:
iscU
Similar to mitochondrial Iron sulfur cluster assembly protein 1; NifU homolog involved in Fe-S cluster formation.
  
 
 0.875
ACPL_1874
Spermidine/putrescine import ATP-binding protein potA; ABC-type oligopeptide transport system, ATPase component.
 
  
 0.744
ACPL_1872
Uncharacterized protein; ABC-type transport system involved in Fe-S cluster assembly, permease component.
 
 
 0.732
sufB
ABC-type transport system involved in Fe-S cluster assembly, permease component.
 
 
 0.725
sufE
SufE protein probably involved in Fe-S center assembly.
  
 
 0.631
ACPL_3847
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate synthase; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
       0.515
ACPL_3849
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
    0.491
ACPL_3850
Nitrate/nitrite sensor protein narQ; Signal transduction histidine kinase.
       0.482
egtD
Uncharacterized protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family.
  
  
 0.441
egtB
Sulfatase-modifying factor 1; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family.
  
  
 0.426
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.