ACPL_395 protein (Actinoplanes sp. SE50110) - STRING interaction network

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Score

ACPL_395

ywjB-like uncharacterized protein; Dihydrofolate reductase. (204 aa)

Predicted Functional Partners:

thyA

0.710

ACPL_396

0.530

ACPL_397

0.455

clpX

0.405

ACPL_4903

0.405

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_395	ACPL_396	ACPL_395	ACPL_396	ywjB-like uncharacterized protein; Dihydrofolate reductase.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.530
ACPL_395	ACPL_397	ACPL_395	ACPL_397	ywjB-like uncharacterized protein; Dihydrofolate reductase.	Serine phosphatase RsbU, regulator of sigma subunit.	0.455
ACPL_395	ACPL_4903	ACPL_395	ACPL_4903	ywjB-like uncharacterized protein; Dihydrofolate reductase.	ATP-dependent protease Clp, ATPase subunit.	0.405
ACPL_395	clpX	ACPL_395	ACPL_1355	ywjB-like uncharacterized protein; Dihydrofolate reductase.	ATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.405
ACPL_395	thyA	ACPL_395	ACPL_7080	ywjB-like uncharacterized protein; Dihydrofolate reductase.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.710
ACPL_396	ACPL_395	ACPL_396	ACPL_395	ywjB-like uncharacterized protein; Dihydrofolate reductase.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.530
ACPL_396	ACPL_397	ACPL_396	ACPL_397	ywjB-like uncharacterized protein; Dihydrofolate reductase.	Serine phosphatase RsbU, regulator of sigma subunit.	0.668
ACPL_396	ACPL_4903	ACPL_396	ACPL_4903	ywjB-like uncharacterized protein; Dihydrofolate reductase.	ATP-dependent protease Clp, ATPase subunit.	0.405
ACPL_396	clpX	ACPL_396	ACPL_1355	ywjB-like uncharacterized protein; Dihydrofolate reductase.	ATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.405
ACPL_396	thyA	ACPL_396	ACPL_7080	ywjB-like uncharacterized protein; Dihydrofolate reductase.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.710
ACPL_397	ACPL_395	ACPL_397	ACPL_395	Serine phosphatase RsbU, regulator of sigma subunit.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.455
ACPL_397	ACPL_396	ACPL_397	ACPL_396	Serine phosphatase RsbU, regulator of sigma subunit.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.668
ACPL_4903	ACPL_395	ACPL_4903	ACPL_395	ATP-dependent protease Clp, ATPase subunit.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.405
ACPL_4903	ACPL_396	ACPL_4903	ACPL_396	ATP-dependent protease Clp, ATPase subunit.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.405
clpX	ACPL_395	ACPL_1355	ACPL_395	ATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.405
clpX	ACPL_396	ACPL_1355	ACPL_396	ATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.405
thyA	ACPL_395	ACPL_7080	ACPL_395	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.710
thyA	ACPL_396	ACPL_7080	ACPL_396	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.710