ACPL_396 protein (Actinoplanes sp. SE50110) - STRING interaction network

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Score

ACPL_396

ywjB-like uncharacterized protein; Dihydrofolate reductase. (187 aa)

Predicted Functional Partners:

thyA

0.776

ACPL_397

0.668

ACPL_395

0.531

ACPL_398

0.492

ACPL_399

0.424

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_395	ACPL_396	ACPL_395	ACPL_396	ywjB-like uncharacterized protein; Dihydrofolate reductase.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.531
ACPL_395	ACPL_397	ACPL_395	ACPL_397	ywjB-like uncharacterized protein; Dihydrofolate reductase.	Serine phosphatase RsbU, regulator of sigma subunit.	0.455
ACPL_395	thyA	ACPL_395	ACPL_7080	ywjB-like uncharacterized protein; Dihydrofolate reductase.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.776
ACPL_396	ACPL_395	ACPL_396	ACPL_395	ywjB-like uncharacterized protein; Dihydrofolate reductase.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.531
ACPL_396	ACPL_397	ACPL_396	ACPL_397	ywjB-like uncharacterized protein; Dihydrofolate reductase.	Serine phosphatase RsbU, regulator of sigma subunit.	0.668
ACPL_396	ACPL_398	ACPL_396	ACPL_398	ywjB-like uncharacterized protein; Dihydrofolate reductase.	GAF sensor hybrid histidine kinase; FOG: HAMP domain.	0.492
ACPL_396	ACPL_399	ACPL_396	ACPL_399	ywjB-like uncharacterized protein; Dihydrofolate reductase.	Chemotaxis response regulator protein-glutamate methylesterase; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.424
ACPL_396	thyA	ACPL_396	ACPL_7080	ywjB-like uncharacterized protein; Dihydrofolate reductase.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.776
ACPL_397	ACPL_395	ACPL_397	ACPL_395	Serine phosphatase RsbU, regulator of sigma subunit.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.455
ACPL_397	ACPL_396	ACPL_397	ACPL_396	Serine phosphatase RsbU, regulator of sigma subunit.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.668
ACPL_397	ACPL_398	ACPL_397	ACPL_398	Serine phosphatase RsbU, regulator of sigma subunit.	GAF sensor hybrid histidine kinase; FOG: HAMP domain.	0.938
ACPL_397	ACPL_399	ACPL_397	ACPL_399	Serine phosphatase RsbU, regulator of sigma subunit.	Chemotaxis response regulator protein-glutamate methylesterase; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.716
ACPL_398	ACPL_396	ACPL_398	ACPL_396	GAF sensor hybrid histidine kinase; FOG: HAMP domain.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.492
ACPL_398	ACPL_397	ACPL_398	ACPL_397	GAF sensor hybrid histidine kinase; FOG: HAMP domain.	Serine phosphatase RsbU, regulator of sigma subunit.	0.938
ACPL_398	ACPL_399	ACPL_398	ACPL_399	GAF sensor hybrid histidine kinase; FOG: HAMP domain.	Chemotaxis response regulator protein-glutamate methylesterase; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.978
ACPL_399	ACPL_396	ACPL_399	ACPL_396	Chemotaxis response regulator protein-glutamate methylesterase; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.424
ACPL_399	ACPL_397	ACPL_399	ACPL_397	Chemotaxis response regulator protein-glutamate methylesterase; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Serine phosphatase RsbU, regulator of sigma subunit.	0.716
ACPL_399	ACPL_398	ACPL_399	ACPL_398	Chemotaxis response regulator protein-glutamate methylesterase; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	GAF sensor hybrid histidine kinase; FOG: HAMP domain.	0.978
thyA	ACPL_395	ACPL_7080	ACPL_395	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.776
thyA	ACPL_396	ACPL_7080	ACPL_396	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	ywjB-like uncharacterized protein; Dihydrofolate reductase.	0.776