Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
hemL-3Glutamate-1-semialdehyde aminotransferase. (447 aa)    
Predicted Functional Partners:
hemB
Porphobilinogen synthase; Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.991
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.988
baeN
Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.
 
 
 0.976
nrps1A
Amino acid adenylation domain-containing protein; Non-ribosomal peptide synthetase modules and related proteins.
 
 
 0.960
nrps1B
Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.953
ACPL_6195
Polyketide synthase modules and related proteins.
    
 0.937
ACPL_405
Phosphoglycerate mutase; Fructose-2,6-bisphosphatase.
  
    0.932
resA
Alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen; Thiol-disulfide isomerase and thioredoxins.
  
  
 0.932
tycC
Non-ribosomal peptide synthetase modules and related proteins.
   
 0.925
hemL-2
Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 
0.924
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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