STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_40422-hydroxy-3-oxopropionate reductase; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (253 aa)    
Predicted Functional Partners:
ACPL_4041
Endoribonuclease L-PSP; Putative translation initiation inhibitor, yjgF family.
       0.781
ACPL_4043
Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.
 
   
 0.652
ACPL_2370
4-carboxymuconolactone decarboxylase; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
 
  
 0.617
ACPL_4034
Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit.
 
  
 0.594
fadB
3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase.
  
  
 0.465
fadB-2
3-hydroxyacyl-CoA dehydrogenase.
  
  
 0.465
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
      
 0.453
ACPL_4044
Amidohydrolase 2; Predicted metal-dependent hydrolase of the TIM-barrel fold.
       0.452
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
      
 0.448
fadH
2,4-dienoyl-CoA reductase (NADPH2); NADH:flavin oxidoreductases, Old Yellow Enzyme family.
 
    0.405
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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