Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACPL_4155GAF sensor signal transduction histidine kinase; FOG: GAF domain. (571 aa)    
Predicted Functional Partners:
ACPL_4156
Transcriptional regulatory protein degU; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 0.990
ACPL_4154
Hypothetical protein; Nitroreductase.
 
     0.697
barA
Sensory box histidine kinase/response regulator; Signal transduction histidine kinase.
  
 
 0.637
ACPL_398
GAF sensor hybrid histidine kinase; FOG: HAMP domain.
  
 
 0.615
degU
Transcriptional regulatory protein degU; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 
 0.580
ACPL_3707
Sensor histidine kinase/response regulator; FOG: HAMP domain.
  
 
 0.551
phoR
Sensory box histidine kinase PhoR; Signal transduction histidine kinase.
  
 
 0.539
ACPL_3427
Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.
  
 
 0.539
etr2-2
Ethylene receptor 2; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
   
 
 0.532
ACPL_4649
Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.
  
 
 0.528
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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