Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
adhThreonine dehydrogenase and related Zn-dependent dehydrogenases. (343 aa)    
Predicted Functional Partners:
ACPL_4172
Hypothetical protein; Zn-dependent hydrolases, including glyoxylases.
  
    0.777
tdh
L-threonine 3-dehydrogenase; Threonine dehydrogenase and related Zn-dependent dehydrogenases.
  
     0.774
ACPL_4171
Fatty acid metabolism regulator protein; Transcriptional regulators.
     
 0.773
ACPL_4170
Autoinducer 2-binding protein lsrB; ABC-type sugar transport system, periplasmic component.
  
    0.754
gno
Gluconate 5-dehydrogenase; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).
 
 
  0.585
ACPL_4174
Transcriptional regulators.
 
   
 0.583
ald1
NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family.
  
 0.572
ACPL_7426
NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family.
  
 0.572
ACPL_7755
NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family.
  
 0.572
ACPL_4166
Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
  
 0.571
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.