Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ACPL_4323Histidine kinase. (165 aa)    
Predicted Functional Partners:
ACPL_2119
Hypothetical protein.
  
     0.611
ACPL_1448
ADAM 12 protein.
  
     0.499
ACPL_4198
Hypothetical protein.
  
     0.484
ACPL_4974
Hypothetical protein; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs.
  
     0.450
ACPL_5822
yxjL-like uncharacterized transcriptional regulatory protein; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.
  
   0.438
ACPL_4324
Leucine-responsive regulatory protein; Transcriptional regulators.
       0.426
ACPL_4988
Hypothetical protein.
  
     0.418
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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