pepA protein (Actinoplanes sp. SE50110) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

pepA

Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain. (396 aa)

Predicted Functional Partners:

hhoB

0.763

arc

0.639

ACPL_5035

0.564

fdh-2

0.548

ACPL_4455

0.547

gpsI

0.518

ank2

0.483

ACPL_4457

0.476

ACPL_4458

0.476

ACPL_2260

0.463

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_2260	hhoB	ACPL_2260	ACPL_7088	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Peptidase S1 and S6 chymotrypsin/Hap; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.463
ACPL_2260	pepA	ACPL_2260	ACPL_4456	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.463
ACPL_4455	fdh-2	ACPL_4455	ACPL_4454	Hypothetical protein.	Alcohol dehydrogenase GroES domain protein; Threonine dehydrogenase and related Zn-dependent dehydrogenases.	0.799
ACPL_4455	pepA	ACPL_4455	ACPL_4456	Hypothetical protein.	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.547
ACPL_4457	ACPL_4458	ACPL_4457	ACPL_4458	Hypothetical protein.	Putative N-acetyltransferase; Histone acetyltransferase HPA2 and related acetyltransferases.	0.773
ACPL_4457	pepA	ACPL_4457	ACPL_4456	Hypothetical protein.	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.476
ACPL_4458	ACPL_4457	ACPL_4458	ACPL_4457	Putative N-acetyltransferase; Histone acetyltransferase HPA2 and related acetyltransferases.	Hypothetical protein.	0.773
ACPL_4458	pepA	ACPL_4458	ACPL_4456	Putative N-acetyltransferase; Histone acetyltransferase HPA2 and related acetyltransferases.	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.476
ACPL_5035	hhoB	ACPL_5035	ACPL_7088	Conserved repeat domain protein.	Peptidase S1 and S6 chymotrypsin/Hap; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.564
ACPL_5035	pepA	ACPL_5035	ACPL_4456	Conserved repeat domain protein.	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.564
ank2	arc	ACPL_4494	ACPL_5247	Ankyrin-2; FOG: Ankyrin repeat.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.531
ank2	hhoB	ACPL_4494	ACPL_7088	Ankyrin-2; FOG: Ankyrin repeat.	Peptidase S1 and S6 chymotrypsin/Hap; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.547
ank2	pepA	ACPL_4494	ACPL_4456	Ankyrin-2; FOG: Ankyrin repeat.	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.483
arc	ank2	ACPL_5247	ACPL_4494	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	Ankyrin-2; FOG: Ankyrin repeat.	0.531
arc	hhoB	ACPL_5247	ACPL_7088	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	Peptidase S1 and S6 chymotrypsin/Hap; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.639
arc	pepA	ACPL_5247	ACPL_4456	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.639
fdh-2	ACPL_4455	ACPL_4454	ACPL_4455	Alcohol dehydrogenase GroES domain protein; Threonine dehydrogenase and related Zn-dependent dehydrogenases.	Hypothetical protein.	0.799
fdh-2	pepA	ACPL_4454	ACPL_4456	Alcohol dehydrogenase GroES domain protein; Threonine dehydrogenase and related Zn-dependent dehydrogenases.	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.548
gpsI	hhoB	ACPL_7204	ACPL_7088	Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.	Peptidase S1 and S6 chymotrypsin/Hap; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.450
gpsI	pepA	ACPL_7204	ACPL_4456	Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.	0.518