STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_4663GDP-mannose pyrophosphatase nudK; NTP pyrophosphohydrolases including oxidative damage repair enzymes. (215 aa)    
Predicted Functional Partners:
nnrE
Uncharacterized protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both [...]
  
 0.885
rnr
Exoribonuclease R.
   
 0.672
ACPL_4662
Glycerol-3-phosphate regulon repressor; Transcriptional regulators of sugar metabolism.
 
     0.645
ACPL_4664
Putative transcriptional regulator ycf27; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
       0.618
rph
Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
    
 0.513
ddx5
DEAD/DEAH box helicase domain-containing protein; Superfamily II DNA and RNA helicases.
   
 0.423
deaD
Cold-shock DEAD box protein A; Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.
   
 0.423
ACPL_6666
Pre-mRNA-processing ATP-dependent RNA helicase PRP5; Superfamily II DNA and RNA helicases.
   
 0.423
ACPL_717
Pre-mRNA-processing ATP-dependent RNA helicase PRP5; Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family.
   
 0.423
ACPL_4144
Hypothetical protein; 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family.
  
     0.402
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.