Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACPL_4692Short-chain dehydrogenase/reductase SDR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (261 aa)    
Predicted Functional Partners:
baeN
Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.
  
 0.900
nrps1A
Amino acid adenylation domain-containing protein; Non-ribosomal peptide synthetase modules and related proteins.
  
 0.781
nrps1B
Non-ribosomal peptide synthetase modules and related proteins.
  
 0.781
pks2A
Polyketide synthase modules and related proteins.
  
 0.775
ACPL_4693
Ribosomal protein L11 methyltransferase; Methylase of polypeptide chain release factors; Belongs to the methyltransferase superfamily.
  
    0.774
ACPL_4690
HTH-type transcriptional activator rhaS; Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain.
       0.773
ACPL_4691
Protein DJ-1; Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain.
       0.773
ACPL_4694
Carboxylate-amine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
       0.773
pks1B
Polyketide synthase modules and related proteins.
  
 0.769
pks3B
Polyketide synthase modules and related proteins.
  
 0.769
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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