ACPL_4863 protein (Actinoplanes sp. SE50110)

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ACPL_4863

Preprotein translocase subunit SecA (ATPase, RNA helicase). (327 aa)

Predicted Functional Partners:

secY

0.933

secE

0.892

secG

0.891

baeN

0.734

polA

0.725

secD

0.701

phoA-2

0.693

nrps1A

0.657

nrps1B

0.657

ACPL_4864

0.635

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_4863	ACPL_4864	ACPL_4863	ACPL_4864	Preprotein translocase subunit SecA (ATPase, RNA helicase).	Lipoate-protein ligase A.	0.635
ACPL_4863	baeN	ACPL_4863	ACPL_6194	Preprotein translocase subunit SecA (ATPase, RNA helicase).	Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.	0.734
ACPL_4863	nrps1A	ACPL_4863	ACPL_1013	Preprotein translocase subunit SecA (ATPase, RNA helicase).	Amino acid adenylation domain-containing protein; Non-ribosomal peptide synthetase modules and related proteins.	0.657
ACPL_4863	nrps1B	ACPL_4863	ACPL_1014	Preprotein translocase subunit SecA (ATPase, RNA helicase).	Non-ribosomal peptide synthetase modules and related proteins.	0.657
ACPL_4863	phoA-2	ACPL_4863	ACPL_6867	Preprotein translocase subunit SecA (ATPase, RNA helicase).	Alkaline phosphatase; Belongs to the alkaline phosphatase family.	0.693
ACPL_4863	polA	ACPL_4863	ACPL_1827	Preprotein translocase subunit SecA (ATPase, RNA helicase).	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.725
ACPL_4863	secD	ACPL_4863	ACPL_6531	Preprotein translocase subunit SecA (ATPase, RNA helicase).	Protein-export membrane protein secD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.	0.701
ACPL_4863	secE	ACPL_4863	ACPL_766	Preprotein translocase subunit SecA (ATPase, RNA helicase).	Putative preprotein translocase subunit secE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.	0.892
ACPL_4863	secG	ACPL_4863	ACPL_1857	Preprotein translocase subunit SecA (ATPase, RNA helicase).	Protein-export membrane protein secG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.	0.891
ACPL_4863	secY	ACPL_4863	ACPL_802	Preprotein translocase subunit SecA (ATPase, RNA helicase).	Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.	0.933
ACPL_4864	ACPL_4863	ACPL_4864	ACPL_4863	Lipoate-protein ligase A.	Preprotein translocase subunit SecA (ATPase, RNA helicase).	0.635
baeN	ACPL_4863	ACPL_6194	ACPL_4863	Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.	Preprotein translocase subunit SecA (ATPase, RNA helicase).	0.734
baeN	nrps1A	ACPL_6194	ACPL_1013	Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.	Amino acid adenylation domain-containing protein; Non-ribosomal peptide synthetase modules and related proteins.	0.999
baeN	nrps1B	ACPL_6194	ACPL_1014	Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.	Non-ribosomal peptide synthetase modules and related proteins.	0.999
baeN	polA	ACPL_6194	ACPL_1827	Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.624
baeN	secD	ACPL_6194	ACPL_6531	Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.	Protein-export membrane protein secD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.	0.402
baeN	secY	ACPL_6194	ACPL_802	Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.	Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.	0.469
nrps1A	ACPL_4863	ACPL_1013	ACPL_4863	Amino acid adenylation domain-containing protein; Non-ribosomal peptide synthetase modules and related proteins.	Preprotein translocase subunit SecA (ATPase, RNA helicase).	0.657
nrps1A	baeN	ACPL_1013	ACPL_6194	Amino acid adenylation domain-containing protein; Non-ribosomal peptide synthetase modules and related proteins.	Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.	0.999
nrps1A	nrps1B	ACPL_1013	ACPL_1014	Amino acid adenylation domain-containing protein; Non-ribosomal peptide synthetase modules and related proteins.	Non-ribosomal peptide synthetase modules and related proteins.	0.999