ACPL_4891 protein (Actinoplanes sp. SE50110)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

ACPL_4891

Transcription elongation factor SPT5. (172 aa)

Predicted Functional Partners:

clpS

0.680

dnaK-3

0.599

grpE

0.595

ACPL_8202

0.595

ACPL_2759

0.569

hspX

0.569

ACPL_6890

0.569

clpP-2

0.555

clpP-3

0.555

clpP

0.555

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_2759	ACPL_4891	ACPL_2759	ACPL_4891	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	Transcription elongation factor SPT5.	0.569
ACPL_2759	ACPL_8202	ACPL_2759	ACPL_8202	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	Hypothetical protein; Molecular chaperone GrpE (heat shock protein).	0.419
ACPL_2759	dnaK-3	ACPL_2759	ACPL_3423	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	Molecular chaperone.	0.512
ACPL_2759	grpE	ACPL_2759	ACPL_201	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.439
ACPL_4891	ACPL_2759	ACPL_4891	ACPL_2759	Transcription elongation factor SPT5.	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	0.569
ACPL_4891	ACPL_6890	ACPL_4891	ACPL_6890	Transcription elongation factor SPT5.	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	0.569
ACPL_4891	ACPL_8202	ACPL_4891	ACPL_8202	Transcription elongation factor SPT5.	Hypothetical protein; Molecular chaperone GrpE (heat shock protein).	0.595
ACPL_4891	clpP	ACPL_4891	ACPL_1841	Transcription elongation factor SPT5.	Protease subunit of ATP-dependent Clp proteases; Belongs to the peptidase S14 family.	0.555
ACPL_4891	clpP-2	ACPL_4891	ACPL_1353	Transcription elongation factor SPT5.	ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.555
ACPL_4891	clpP-3	ACPL_4891	ACPL_1354	Transcription elongation factor SPT5.	ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.555
ACPL_4891	clpS	ACPL_4891	ACPL_1163	Transcription elongation factor SPT5.	ATP-dependent Clp protease adapter protein clpS; Belongs to the ClpS family.	0.680
ACPL_4891	dnaK-3	ACPL_4891	ACPL_3423	Transcription elongation factor SPT5.	Molecular chaperone.	0.599
ACPL_4891	grpE	ACPL_4891	ACPL_201	Transcription elongation factor SPT5.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.595
ACPL_4891	hspX	ACPL_4891	ACPL_3351	Transcription elongation factor SPT5.	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	0.569
ACPL_6890	ACPL_4891	ACPL_6890	ACPL_4891	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	Transcription elongation factor SPT5.	0.569
ACPL_6890	ACPL_8202	ACPL_6890	ACPL_8202	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	Hypothetical protein; Molecular chaperone GrpE (heat shock protein).	0.419
ACPL_6890	dnaK-3	ACPL_6890	ACPL_3423	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	Molecular chaperone.	0.512
ACPL_6890	grpE	ACPL_6890	ACPL_201	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.439
ACPL_8202	ACPL_2759	ACPL_8202	ACPL_2759	Hypothetical protein; Molecular chaperone GrpE (heat shock protein).	Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.	0.419
ACPL_8202	ACPL_4891	ACPL_8202	ACPL_4891	Hypothetical protein; Molecular chaperone GrpE (heat shock protein).	Transcription elongation factor SPT5.	0.595