STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
holBDNA polymerase III subunit delta; ATPase involved in DNA replication. (394 aa)    
Predicted Functional Partners:
ACPL_1392
DNA polymerase III, delta subunit.
 
 
 0.995
dnaN
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 
 0.990
dnaE-2
DNA polymerase III, alpha subunit.
 
 0.990
dnaQ
DNA polymerase III, alpha subunit (gram-positive type).
   
 0.977
ACPL_1659
DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.
 
 0.961
dnaZ
DNA polymerase III, gamma/tau subunits.
  
  
 
0.924
ACPL_7634
DNA polymerase sliding clamp subunit (PCNA homolog).
   
 
 0.902
dnaE
DNA polymerase III subunit alpha; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.
 
 
 0.895
ACPL_7625
Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily.
 
  
 0.787
ACPL_7626
Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily.
 
  
 0.781
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.