Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dhbBIsochorismatase hydrolase; Amidases related to nicotinamidase. (178 aa)    
Predicted Functional Partners:
ACPL_2961
Isochorismatase hydrolase; Amidases related to nicotinamidase.
  
     0.710
ACPL_3603
Isochorismatase hydrolase; Amidases related to nicotinamidase.
  
     0.572
baeN
Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.533
trpE-2
Salicylate synthetase; Anthranilate/para-aminobenzoate synthases component I.
    
 0.526
ACPL_5031
Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
  
   0.525
ACPL_2419
3-oxoacyl-[acyl-carrier protein] reductase; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).
    
  0.514
nnrE
Uncharacterized protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both [...]
  
    0.510
ACPL_5030
Hypothetical protein.
       0.503
nrps1A
Amino acid adenylation domain-containing protein; Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.486
nrps1B
Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.486
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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