Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACPL_5094Putative signaling protein; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (721 aa)    
Predicted Functional Partners:
ACPL_2318
Signal transduction histidine kinase.
  
 
 0.929
barA
Sensory box histidine kinase/response regulator; Signal transduction histidine kinase.
  
 
 0.906
ACPL_4649
Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.
  
 
 0.904
ACPL_4809
Two-component system sensor protein; Signal transduction histidine kinase.
  
 
 0.901
ACPL_2274
Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
  
 0.869
ACPL_4800
Two-component system, cell cycle sensor kinase and response regulator; Signal transduction histidine kinase.
  
 
 0.846
ACPL_5711
Cellulose synthesis regulatory protein; FOG: GGDEF domain.
 
 
 0.820
ACPL_397
Serine phosphatase RsbU, regulator of sigma subunit.
  
 
 0.798
ACPL_5096
Putative signaling protein; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.
 
 
0.795
ACPL_4686
Putative signaling protein; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.
 
 
0.778
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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