Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACPL_5192Two-component system, OmpR family, sensor histidine kinase MprB; Signal transduction histidine kinase. (478 aa)    
Predicted Functional Partners:
mprA
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 0.995
ACPL_580
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
   0.748
tcrA-2
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 
 0.745
phoP
Transcriptional regulatory protein yycF; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 
 0.739
ACPL_7878
Sensory transduction protein regX3; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 
 0.737
ACPL_4806
Putative transcriptional regulator ycf27; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 
 0.736
ACPL_2319
Putative transcriptional regulator ycf27; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 
 0.729
rcaC
Protein rcaC; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 
 0.727
ACPL_5063
Alkaline phosphatase synthesis transcriptional regulatory protein sphR; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 
 0.727
tcrA
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 
 0.726
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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