Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
kuDNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (305 aa)    
Predicted Functional Partners:
ligC
ATP-dependent DNA ligase.
 
  
 0.958
ACPL_519
DNA ligase (ATP); Predicted eukaryotic-type DNA primase.
 
  
 0.956
ACPL_520
ATP-dependent DNA ligase.
 
  
 0.933
ligC-2
ATP-dependent DNA ligase.
 
  
 0.932
ACPL_7020
DNA ligase (ATP); Predicted eukaryotic-type DNA primase.
 
  
 0.885
ACPL_7075
DNA ligase (ATP); Predicted eukaryotic-type DNA primase.
 
  
 0.885
ACPL_6882
Hypothetical protein; Predicted eukaryotic-type DNA primase.
 
  
 0.867
ligD
ATP-dependent DNA ligase.
 
  
 0.859
ligB
ATP-dependent DNA ligase.
 
  
 0.813
ACPL_7625
Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily.
     
 0.744
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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