pup protein (Actinoplanes sp. SE50110) - STRING interaction network

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pup

Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. (71 aa)

Predicted Functional Partners:

arc

0.992

ACPL_5245

0.933

pafA

0.929

prcA

0.928

prcB

0.925

ACPL_8311

0.729

fdxG

0.555

ACPL_8093

0.526

ACPL_719

0.511

ACPL_7140

0.464

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_5245	ACPL_719	ACPL_5245	ACPL_719	Hypothetical protein.	HTH-type protein slmA; Transcriptional regulator.	0.463
ACPL_5245	ACPL_8311	ACPL_5245	ACPL_8311	Hypothetical protein.	Uncharacterized protein.	0.682
ACPL_5245	arc	ACPL_5245	ACPL_5247	Hypothetical protein.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.939
ACPL_5245	fdxG	ACPL_5245	ACPL_5248	Hypothetical protein.	Ferredoxin.	0.569
ACPL_5245	pafA	ACPL_5245	ACPL_5241	Hypothetical protein.	Proteasome accessory factor A; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.	0.494
ACPL_5245	prcA	ACPL_5245	ACPL_5242	Hypothetical protein.	Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.	0.893
ACPL_5245	prcB	ACPL_5245	ACPL_5243	Hypothetical protein.	Proteasome beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.	0.894
ACPL_5245	pup	ACPL_5245	ACPL_5244	Hypothetical protein.	Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.	0.933
ACPL_7140	arc	ACPL_7140	ACPL_5247	CoA-binding domain protein; Acyl-CoA synthetase (NDP forming).	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.466
ACPL_7140	pup	ACPL_7140	ACPL_5244	CoA-binding domain protein; Acyl-CoA synthetase (NDP forming).	Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.	0.464
ACPL_719	ACPL_5245	ACPL_719	ACPL_5245	HTH-type protein slmA; Transcriptional regulator.	Hypothetical protein.	0.463
ACPL_719	pafA	ACPL_719	ACPL_5241	HTH-type protein slmA; Transcriptional regulator.	Proteasome accessory factor A; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.	0.401
ACPL_719	pup	ACPL_719	ACPL_5244	HTH-type protein slmA; Transcriptional regulator.	Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.	0.511
ACPL_8093	pup	ACPL_8093	ACPL_5244	Hypothetical protein.	Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.	0.526
ACPL_8311	ACPL_5245	ACPL_8311	ACPL_5245	Uncharacterized protein.	Hypothetical protein.	0.682
ACPL_8311	arc	ACPL_8311	ACPL_5247	Uncharacterized protein.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.914
ACPL_8311	pafA	ACPL_8311	ACPL_5241	Uncharacterized protein.	Proteasome accessory factor A; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.	0.752
ACPL_8311	prcA	ACPL_8311	ACPL_5242	Uncharacterized protein.	Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.	0.976
ACPL_8311	prcB	ACPL_8311	ACPL_5243	Uncharacterized protein.	Proteasome beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.	0.943
ACPL_8311	pup	ACPL_8311	ACPL_5244	Uncharacterized protein.	Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.	0.729

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