STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobEProtein cobE; Cobalamin biosynthesis protein CbiG. (114 aa)    
Predicted Functional Partners:
cobM
Precorrin-4 methylase; Belongs to the precorrin methyltransferase family.
  
 
 0.997
cobL
precorrin-6Y C5,15-methyltransferase / precorrin-8W decarboxylase; Precorrin-6B methylase 1.
 
  
 0.987
cobQ
Adenosylcobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.985
cobI
Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Precorrin-3B methylase.
  
  
 0.985
cobH
precorrin-8X methylmutase; Precorrin isomerase.
 
  
 0.983
cobK
Precorrin-6x reductase.
  
  
 0.979
cobB-2
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
  
 0.976
cobS
adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.969
cobF
precorrin-6A synthase; Uroporphyrinogen-III methylase.
  
  
 0.968
btuR
ATP:corrinoid adenosyltransferase.
 
   
 0.956
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.