Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACPL_5469Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria). (350 aa)    
Predicted Functional Partners:
ptsH
Phosphotransferase system, HPr-related proteins.
  
 0.983
hpr
Phosphotransferase system, HPr-related proteins.
  
 0.976
ptsI
Phosphotransferase system, enzyme I, PtsI; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
  
  
 
0.905
ACPL_5491
PTS-dependent dihydroxyacetone kinase, phosphotransferase subunit dhaM; Phosphotransferase system, mannose/fructose-specific component IIA.
  
 
 0.840
ACPL_5470
Predicted membrane protein.
       0.686
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
   
  
 0.585
ACPL_5471
Sphingomyelin phosphodiesterase 2.
       0.513
ACPL_1513
PfkB domain protein; Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB).
  
  
 0.436
ACPL_6373
Phosphofructokinase; Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Belongs to the carbohydrate kinase PfkB family.
  
  
 0.436
tig
Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
  
  
 0.423
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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