Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pdxH-2Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (224 aa)    
Predicted Functional Partners:
snz1
Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.
  
 
 0.950
pdxT
Glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
    
 0.944
ACPL_2122
Pyridoxamine-phosphate oxidase.
  
  
 
0.921
pdxH
Pyridoxamine-phosphate oxidase.
  
  
 
0.920
pdxY
Pyridoxal/pyridoxine/pyridoxamine kinase; Belongs to the pyridoxine kinase family.
    
 0.914
ACPL_4327
Aldo-keto reductase-like family 1 member C1 protein; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases).
     
  0.900
ACPL_4380
Predicted oxidoreductases (related to aryl-alcohol dehydrogenases).
     
  0.900
yihR
Aldose 1-epimerase; Galactose mutarotase and related enzymes.
       0.839
ACPL_551
Permeases of the major facilitator superfamily.
       0.801
ACPL_553
NADPH-dependent oxidoreductase; Nitroreductase.
  
  
 0.785
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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