Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_5512Regulator of nonsense transcripts-like protein; Superfamily I DNA and RNA helicases and helicase subunits. (1732 aa)    
Predicted Functional Partners:
ACPL_5371
Polycystic kidney disease protein 1-like 3; Predicted drug exporters of the RND superfamily.
 
     0.681
gltB
Glutamate synthase domain 2.
  
    0.674
ACPL_2139
Hypothetical protein; Superfamily I DNA and RNA helicases and helicase subunits.
 
     0.663
ACPL_3629
Hypothetical protein; FOG: WD40 repeat.
  
     0.647
ACPL_8011
Hypothetical protein.
  
  
 0.644
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
  
 
  0.638
ndhD
NAD(P)H-quinone oxidoreductase chain 4; Similar to chloroplast protein; Membrane protein involved in the export of O-antigen and teichoic acid.
 
     0.628
ruvA
Holliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
    
  0.617
ACPL_3454
Hypothetical protein.
  
    0.606
ACPL_6563
Hypothetical protein.
  
    0.606
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
Server load: medium (44%) [HD]