tdk protein (Actinoplanes sp. SE50110) - STRING interaction network

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Predicted Interactions

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Score

tdk

Thymidine kinase. (217 aa)

Predicted Functional Partners:

dut

0.977

thyA

0.961

deoA

0.945

tmk

0.940

deoD

0.932

cdd

0.927

ACPL_1266

0.923

ACPL_680

0.915

ACPL_888

0.903

surE

0.900

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_1266	ACPL_680	ACPL_1266	ACPL_680	Thymidylate kinase; ABC-type sugar transport systems, ATPase components.	5'-nucleotidase; Predicted extracellular nuclease.	0.915
ACPL_1266	ACPL_888	ACPL_1266	ACPL_888	Thymidylate kinase; ABC-type sugar transport systems, ATPase components.	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family.	0.913
ACPL_1266	dut	ACPL_1266	ACPL_7108	Thymidylate kinase; ABC-type sugar transport systems, ATPase components.	dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	0.935
ACPL_1266	surE	ACPL_1266	ACPL_1512	Thymidylate kinase; ABC-type sugar transport systems, ATPase components.	5'-nucleotidase; Predicted acid phosphatase.	0.907
ACPL_1266	tdk	ACPL_1266	ACPL_5558	Thymidylate kinase; ABC-type sugar transport systems, ATPase components.	Thymidine kinase.	0.923
ACPL_1266	thyA	ACPL_1266	ACPL_7080	Thymidylate kinase; ABC-type sugar transport systems, ATPase components.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.931
ACPL_1266	tmk	ACPL_1266	ACPL_494	Thymidylate kinase; ABC-type sugar transport systems, ATPase components.	dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.900
ACPL_680	ACPL_1266	ACPL_680	ACPL_1266	5'-nucleotidase; Predicted extracellular nuclease.	Thymidylate kinase; ABC-type sugar transport systems, ATPase components.	0.915
ACPL_680	ACPL_888	ACPL_680	ACPL_888	5'-nucleotidase; Predicted extracellular nuclease.	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family.	0.958
ACPL_680	cdd	ACPL_680	ACPL_7768	5'-nucleotidase; Predicted extracellular nuclease.	Cytidine deaminase.	0.929
ACPL_680	deoA	ACPL_680	ACPL_7767	5'-nucleotidase; Predicted extracellular nuclease.	Thymidine phosphorylase.	0.923
ACPL_680	deoD	ACPL_680	ACPL_8137	5'-nucleotidase; Predicted extracellular nuclease.	Purine-nucleoside phosphorylase.	0.917
ACPL_680	dut	ACPL_680	ACPL_7108	5'-nucleotidase; Predicted extracellular nuclease.	dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	0.900
ACPL_680	surE	ACPL_680	ACPL_1512	5'-nucleotidase; Predicted extracellular nuclease.	5'-nucleotidase; Predicted acid phosphatase.	0.943
ACPL_680	tdk	ACPL_680	ACPL_5558	5'-nucleotidase; Predicted extracellular nuclease.	Thymidine kinase.	0.915
ACPL_680	thyA	ACPL_680	ACPL_7080	5'-nucleotidase; Predicted extracellular nuclease.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.907
ACPL_680	tmk	ACPL_680	ACPL_494	5'-nucleotidase; Predicted extracellular nuclease.	dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.918
ACPL_888	ACPL_1266	ACPL_888	ACPL_1266	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family.	Thymidylate kinase; ABC-type sugar transport systems, ATPase components.	0.913
ACPL_888	ACPL_680	ACPL_888	ACPL_680	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family.	5'-nucleotidase; Predicted extracellular nuclease.	0.958
ACPL_888	cdd	ACPL_888	ACPL_7768	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family.	Cytidine deaminase.	0.909