afsR-3 protein (Actinoplanes sp. SE50110) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

afsR-3

Regulatory protein afsR; Predicted ATPase. (1022 aa)

Predicted Functional Partners:

rpoB

0.827

nadR

0.822

rpoC

0.821

rpoA

0.821

hrdB

0.771

rpoT

0.771

sigB

0.771

rpoZ

0.769

rbpA-2

0.761

ACPL_8038

0.761

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_8038	afsR-3	ACPL_8038	ACPL_5576	Transcriptional regulators, similar to M. xanthus CarD.	Regulatory protein afsR; Predicted ATPase.	0.761
ACPL_8038	hrdB	ACPL_8038	ACPL_1268	Transcriptional regulators, similar to M. xanthus CarD.	RNA polymerase principal sigma factor hrdB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.856
ACPL_8038	rbpA-2	ACPL_8038	ACPL_2796	Transcriptional regulators, similar to M. xanthus CarD.	Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.	0.969
ACPL_8038	rpoA	ACPL_8038	ACPL_811	Transcriptional regulators, similar to M. xanthus CarD.	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.952
ACPL_8038	rpoB	ACPL_8038	ACPL_773	Transcriptional regulators, similar to M. xanthus CarD.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.946
ACPL_8038	rpoC	ACPL_8038	ACPL_774	Transcriptional regulators, similar to M. xanthus CarD.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.963
ACPL_8038	rpoT	ACPL_8038	ACPL_7114	Transcriptional regulators, similar to M. xanthus CarD.	RNA polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	0.856
ACPL_8038	rpoZ	ACPL_8038	ACPL_6468	Transcriptional regulators, similar to M. xanthus CarD.	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.955
ACPL_8038	sigB	ACPL_8038	ACPL_7139	Transcriptional regulators, similar to M. xanthus CarD.	RNA polymerase principal sigma factor hrdB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.856
afsR-3	ACPL_8038	ACPL_5576	ACPL_8038	Regulatory protein afsR; Predicted ATPase.	Transcriptional regulators, similar to M. xanthus CarD.	0.761
afsR-3	hrdB	ACPL_5576	ACPL_1268	Regulatory protein afsR; Predicted ATPase.	RNA polymerase principal sigma factor hrdB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.771
afsR-3	nadR	ACPL_5576	ACPL_569	Regulatory protein afsR; Predicted ATPase.	Transcriptional regulator nadR; FAD synthase.	0.822
afsR-3	rbpA-2	ACPL_5576	ACPL_2796	Regulatory protein afsR; Predicted ATPase.	Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.	0.761
afsR-3	rpoA	ACPL_5576	ACPL_811	Regulatory protein afsR; Predicted ATPase.	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.821
afsR-3	rpoB	ACPL_5576	ACPL_773	Regulatory protein afsR; Predicted ATPase.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.827
afsR-3	rpoC	ACPL_5576	ACPL_774	Regulatory protein afsR; Predicted ATPase.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.821
afsR-3	rpoT	ACPL_5576	ACPL_7114	Regulatory protein afsR; Predicted ATPase.	RNA polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	0.771
afsR-3	rpoZ	ACPL_5576	ACPL_6468	Regulatory protein afsR; Predicted ATPase.	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.769
afsR-3	sigB	ACPL_5576	ACPL_7139	Regulatory protein afsR; Predicted ATPase.	RNA polymerase principal sigma factor hrdB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.771
hrdB	ACPL_8038	ACPL_1268	ACPL_8038	RNA polymerase principal sigma factor hrdB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Transcriptional regulators, similar to M. xanthus CarD.	0.856