| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EPR75300.1 | EPR76963.1 | ADILRU_2441 | ADILRU_0802 | Ribonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Nucleoside diphosphate kinase. | 0.921 |
| EPR75300.1 | dcd | ADILRU_2441 | ADILRU_0088 | Ribonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxycytidine triphosphate deaminase (dUMP-forming); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.533 |
| EPR75300.1 | dut | ADILRU_2441 | ADILRU_1609 | Ribonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.778 |
| EPR75300.1 | guaA | ADILRU_2441 | ADILRU_1275 | Ribonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.675 |
| EPR75300.1 | polA | ADILRU_2441 | ADILRU_2224 | Ribonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.879 |
| EPR75300.1 | thyA | ADILRU_2441 | ADILRU_0393 | Ribonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.859 |
| EPR75300.1 | tmk | ADILRU_2441 | ADILRU_1342 | Ribonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.881 |
| EPR75803.1 | EPR76963.1 | ADILRU_1973 | ADILRU_0802 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Nucleoside diphosphate kinase. | 0.867 |
| EPR75803.1 | dcd | ADILRU_1973 | ADILRU_0088 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Deoxycytidine triphosphate deaminase (dUMP-forming); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.476 |
| EPR75803.1 | dut | ADILRU_1973 | ADILRU_1609 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.940 |
| EPR75803.1 | guaA | ADILRU_1973 | ADILRU_1275 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.930 |
| EPR76608.1 | dcd | ADILRU_1093 | ADILRU_0088 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. | Deoxycytidine triphosphate deaminase (dUMP-forming); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.618 |
| EPR76963.1 | EPR75300.1 | ADILRU_0802 | ADILRU_2441 | Nucleoside diphosphate kinase. | Ribonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.921 |
| EPR76963.1 | EPR75803.1 | ADILRU_0802 | ADILRU_1973 | Nucleoside diphosphate kinase. | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.867 |
| EPR76963.1 | dcd | ADILRU_0802 | ADILRU_0088 | Nucleoside diphosphate kinase. | Deoxycytidine triphosphate deaminase (dUMP-forming); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.869 |
| EPR76963.1 | dut | ADILRU_0802 | ADILRU_1609 | Nucleoside diphosphate kinase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.946 |
| EPR76963.1 | guaA | ADILRU_0802 | ADILRU_1275 | Nucleoside diphosphate kinase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.628 |
| EPR76963.1 | thyA | ADILRU_0802 | ADILRU_0393 | Nucleoside diphosphate kinase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.428 |
| EPR76963.1 | tmk | ADILRU_0802 | ADILRU_1342 | Nucleoside diphosphate kinase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.924 |
| EPR77394.1 | dcd | ADILRU_0330 | ADILRU_0088 | Thymidine kinase. | Deoxycytidine triphosphate deaminase (dUMP-forming); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.452 |
