node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHM20754.1 | SHM89065.1 | SAMN05443668_1018 | SAMN05443668_10286 | L-ribulose 5-phosphate 4-epimerase. | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | 0.825 |
SHM20754.1 | SHN45922.1 | SAMN05443668_1018 | SAMN05443668_11386 | L-ribulose 5-phosphate 4-epimerase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.610 |
SHM20754.1 | SHN47781.1 | SAMN05443668_1018 | SAMN05443668_1289 | L-ribulose 5-phosphate 4-epimerase. | 5'-methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. | 0.568 |
SHM20754.1 | mtnA | SAMN05443668_1018 | SAMN05443668_102747 | L-ribulose 5-phosphate 4-epimerase. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.670 |
SHM20754.1 | mtnC | SAMN05443668_1018 | SAMN05443668_10285 | L-ribulose 5-phosphate 4-epimerase. | Acireductone synthase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. | 0.715 |
SHM20754.1 | mtnD | SAMN05443668_1018 | SAMN05443668_10272 | L-ribulose 5-phosphate 4-epimerase. | Acireductone dioxygenase apoprotein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.756 |
SHM89065.1 | SHM20754.1 | SAMN05443668_10286 | SAMN05443668_1018 | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | L-ribulose 5-phosphate 4-epimerase. | 0.825 |
SHM89065.1 | SHM89094.1 | SAMN05443668_10286 | SAMN05443668_10287 | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | 5'-methylthioribose kinase. | 0.998 |
SHM89065.1 | SHN04534.1 | SAMN05443668_10286 | SAMN05443668_102701 | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | L-fuculose 1-phosphate aldolase. | 0.903 |
SHM89065.1 | SHN45922.1 | SAMN05443668_10286 | SAMN05443668_11386 | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.858 |
SHM89065.1 | SHN47781.1 | SAMN05443668_10286 | SAMN05443668_1289 | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | 5'-methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. | 0.955 |
SHM89065.1 | mtnA | SAMN05443668_10286 | SAMN05443668_102747 | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.909 |
SHM89065.1 | mtnB | SAMN05443668_10286 | SAMN05443668_10284 | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | 0.996 |
SHM89065.1 | mtnC | SAMN05443668_10286 | SAMN05443668_10285 | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | Acireductone synthase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. | 0.982 |
SHM89065.1 | mtnD | SAMN05443668_10286 | SAMN05443668_10272 | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | Acireductone dioxygenase apoprotein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.888 |
SHM89065.1 | mtnK | SAMN05443668_10286 | SAMN05443668_10276 | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | 5'-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. | 0.924 |
SHM89094.1 | SHM89065.1 | SAMN05443668_10287 | SAMN05443668_10286 | 5'-methylthioribose kinase. | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. | 0.998 |
SHM89094.1 | SHN45922.1 | SAMN05443668_10287 | SAMN05443668_11386 | 5'-methylthioribose kinase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.731 |
SHM89094.1 | SHN47781.1 | SAMN05443668_10287 | SAMN05443668_1289 | 5'-methylthioribose kinase. | 5'-methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. | 0.818 |
SHM89094.1 | mtnA | SAMN05443668_10287 | SAMN05443668_102747 | 5'-methylthioribose kinase. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.998 |