node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHN24209.1 | SHN24220.1 | SAMN05443668_10445 | SAMN05443668_10446 | Dihydrofolate reductase. | Transcriptional regulator, TetR family. | 0.532 |
SHN24209.1 | SHN45922.1 | SAMN05443668_10445 | SAMN05443668_11386 | Dihydrofolate reductase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.717 |
SHN24209.1 | SHN46017.1 | SAMN05443668_10445 | SAMN05443668_113135 | Dihydrofolate reductase. | Thymidine kinase. | 0.514 |
SHN24209.1 | dut | SAMN05443668_10445 | SAMN05443668_101661 | Dihydrofolate reductase. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.460 |
SHN24209.1 | folD | SAMN05443668_10445 | SAMN05443668_11277 | Dihydrofolate reductase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.453 |
SHN24209.1 | purD | SAMN05443668_10445 | SAMN05443668_110104 | Dihydrofolate reductase. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.453 |
SHN24209.1 | purH | SAMN05443668_10445 | SAMN05443668_11280 | Dihydrofolate reductase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.451 |
SHN24209.1 | purN | SAMN05443668_10445 | SAMN05443668_11281 | Dihydrofolate reductase. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.453 |
SHN24209.1 | thyX | SAMN05443668_10445 | SAMN05443668_101570 | Dihydrofolate reductase. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.457 |
SHN24209.1 | tmk | SAMN05443668_10445 | SAMN05443668_102585 | Dihydrofolate reductase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.466 |
SHN24220.1 | SHN24209.1 | SAMN05443668_10446 | SAMN05443668_10445 | Transcriptional regulator, TetR family. | Dihydrofolate reductase. | 0.532 |
SHN45922.1 | SHN24209.1 | SAMN05443668_11386 | SAMN05443668_10445 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase. | 0.717 |
SHN45922.1 | folD | SAMN05443668_11386 | SAMN05443668_11277 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.890 |
SHN45922.1 | purD | SAMN05443668_11386 | SAMN05443668_110104 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.670 |
SHN45922.1 | purH | SAMN05443668_11386 | SAMN05443668_11280 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.871 |
SHN45922.1 | purN | SAMN05443668_11386 | SAMN05443668_11281 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.880 |
SHN45922.1 | thyX | SAMN05443668_11386 | SAMN05443668_101570 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.880 |
SHN46017.1 | SHN24209.1 | SAMN05443668_113135 | SAMN05443668_10445 | Thymidine kinase. | Dihydrofolate reductase. | 0.514 |
SHN46017.1 | dut | SAMN05443668_113135 | SAMN05443668_101661 | Thymidine kinase. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.980 |
SHN46017.1 | thyX | SAMN05443668_113135 | SAMN05443668_101570 | Thymidine kinase. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.908 |