SHN76108.1 protein (Cryptosporangium aurantiacum)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

SHN76108.1

Transcriptional regulator, TetR family. (214 aa)

Predicted Functional Partners:

SHN76113.1

0.656

SHN43342.1

0.575

SHN14766.1

0.544

SHN76101.1

0.541

SHM98384.1

0.497

SHM65683.1

0.495

SHM64632.1

0.459

SHM64657.1

0.437

SHN74756.1

0.406

SHM65778.1

0.402

Your Current Organism:

Cryptosporangium aurantiacum

NCBI taxonomy Id: 134849
Other names: Actinoplanes aurantiacus, C. aurantiacum, DSM 46144, IFO 13967, IMET 9261, IMSNU 22120, JCM 3241, KCC A-0241, KCTC 9529, NBRC 13967, NCIMB 12649, NRRL B-16698, strain 71-C38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHM64632.1	SHM64657.1	SAMN05443668_1011127	SAMN05443668_1011128	Predicted metal-dependent hydrolase, TIM-barrel fold.	Predicted metal-dependent hydrolase, TIM-barrel fold.	0.822
SHM64632.1	SHM65683.1	SAMN05443668_1011127	SAMN05443668_1011165	Predicted metal-dependent hydrolase, TIM-barrel fold.	Sugar lactone lactonase YvrE.	0.760
SHM64632.1	SHN14766.1	SAMN05443668_1011127	SAMN05443668_103217	Predicted metal-dependent hydrolase, TIM-barrel fold.	Transcriptional regulator, TetR family.	0.565
SHM64632.1	SHN43342.1	SAMN05443668_1011127	SAMN05443668_109122	Predicted metal-dependent hydrolase, TIM-barrel fold.	Transcriptional regulator, TetR family.	0.708
SHM64632.1	SHN76108.1	SAMN05443668_1011127	SAMN05443668_107451	Predicted metal-dependent hydrolase, TIM-barrel fold.	Transcriptional regulator, TetR family.	0.459
SHM64657.1	SHM64632.1	SAMN05443668_1011128	SAMN05443668_1011127	Predicted metal-dependent hydrolase, TIM-barrel fold.	Predicted metal-dependent hydrolase, TIM-barrel fold.	0.822
SHM64657.1	SHM65683.1	SAMN05443668_1011128	SAMN05443668_1011165	Predicted metal-dependent hydrolase, TIM-barrel fold.	Sugar lactone lactonase YvrE.	0.729
SHM64657.1	SHN14766.1	SAMN05443668_1011128	SAMN05443668_103217	Predicted metal-dependent hydrolase, TIM-barrel fold.	Transcriptional regulator, TetR family.	0.507
SHM64657.1	SHN43342.1	SAMN05443668_1011128	SAMN05443668_109122	Predicted metal-dependent hydrolase, TIM-barrel fold.	Transcriptional regulator, TetR family.	0.661
SHM64657.1	SHN76108.1	SAMN05443668_1011128	SAMN05443668_107451	Predicted metal-dependent hydrolase, TIM-barrel fold.	Transcriptional regulator, TetR family.	0.437
SHM65683.1	SHM64632.1	SAMN05443668_1011165	SAMN05443668_1011127	Sugar lactone lactonase YvrE.	Predicted metal-dependent hydrolase, TIM-barrel fold.	0.760
SHM65683.1	SHM64657.1	SAMN05443668_1011165	SAMN05443668_1011128	Sugar lactone lactonase YvrE.	Predicted metal-dependent hydrolase, TIM-barrel fold.	0.729
SHM65683.1	SHM65778.1	SAMN05443668_1011165	SAMN05443668_1011168	Sugar lactone lactonase YvrE.	Cyclohexanone monooxygenase.	0.959
SHM65683.1	SHN14766.1	SAMN05443668_1011165	SAMN05443668_103217	Sugar lactone lactonase YvrE.	Transcriptional regulator, TetR family.	0.433
SHM65683.1	SHN43342.1	SAMN05443668_1011165	SAMN05443668_109122	Sugar lactone lactonase YvrE.	Transcriptional regulator, TetR family.	0.629
SHM65683.1	SHN76108.1	SAMN05443668_1011165	SAMN05443668_107451	Sugar lactone lactonase YvrE.	Transcriptional regulator, TetR family.	0.495
SHM65778.1	SHM65683.1	SAMN05443668_1011168	SAMN05443668_1011165	Cyclohexanone monooxygenase.	Sugar lactone lactonase YvrE.	0.959
SHM65778.1	SHN76108.1	SAMN05443668_1011168	SAMN05443668_107451	Cyclohexanone monooxygenase.	Transcriptional regulator, TetR family.	0.402
SHM98384.1	SHN74756.1	SAMN05443668_102413	SAMN05443668_107143	Hypothetical protein.	Transcriptional regulator, TetR family.	0.419
SHM98384.1	SHN76108.1	SAMN05443668_102413	SAMN05443668_107451	Hypothetical protein.	Transcriptional regulator, TetR family.	0.497

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.886

expected number of edges:

11

PPI enrichment p-value:

4.13e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1901663

Quinone biosynthetic process

6 of 22

1.97

3.23

5.40e-08

GO:0009234

Menaquinone biosynthetic process

4 of 5

2.43

3.12

1.03e-06

GO:0044283

Small molecule biosynthetic process

9 of 192

1.2

1.63

5.40e-08

GO:0006744

Ubiquinone biosynthetic process

2 of 5

2.13

0.97

0.0154

GO:0044249

Cellular biosynthetic process

9 of 579

0.72

0.62

0.00030

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016765

Transferase activity, transferring alkyl or aryl (other than methyl) groups

4 of 23

1.77

1.58

0.00044

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4596

Thiamine metabolic process, and Menaquinone biosynthesis

9 of 18

2.23

6.6

4.91e-16

CL:4598

Menaquinone biosynthesis

5 of 6

2.45

4.22

5.30e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00130

Ubiquinone and other terpenoid-quinone biosynthesis

8 of 42

1.81

3.94

1.08e-11

map01110

Biosynthesis of secondary metabolites

9 of 364

0.92

0.98

2.42e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1902508

2-iminoacetate synthase complex

3 of 4

2.41

2.01

0.00017

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0474

Menaquinone biosynthesis

5 of 6

2.45

4.16

7.11e-09

KW-0456

Lyase

4 of 64

1.33

1.01

0.0031

KW-0949

S-adenosyl-L-methionine

3 of 58

1.25

0.61

0.0426

KW-0004

4Fe-4S

3 of 58

1.25

0.61

0.0426

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02621

Menaquinone biosynthesis

2 of 2

2.53

0.88

0.0252

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