SHN46215.1 protein (Cryptosporangium aurantiacum)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

SHN46215.1

Methyl-accepting chemotaxis protein (MCP) signalling domain-containing protein. (111 aa)

Predicted Functional Partners:

SHM59652.1

0.974

SHM72111.1

0.973

SHN46759.1

0.973

SHN42114.1

0.970

SHN45358.1

0.970

SHN75054.1

0.960

SHN47482.1

0.960

SHN42111.1

0.958

SHN45372.1

0.958

SHN43436.1

0.940

Your Current Organism:

Cryptosporangium aurantiacum

NCBI taxonomy Id: 134849
Other names: Actinoplanes aurantiacus, C. aurantiacum, DSM 46144, IFO 13967, IMET 9261, IMSNU 22120, JCM 3241, KCC A-0241, KCTC 9529, NBRC 13967, NCIMB 12649, NRRL B-16698, strain 71-C38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHM59652.1	SHM72111.1	SAMN05443668_101988	SAMN05443668_1011334	CheY chemotaxis protein or a CheY-like REC (receiver) domain.	PAS domain S-box-containing protein.	0.999
SHM59652.1	SHN42111.1	SAMN05443668_101988	SAMN05443668_10883	CheY chemotaxis protein or a CheY-like REC (receiver) domain.	Purine-binding chemotaxis protein CheW.	0.983
SHM59652.1	SHN42114.1	SAMN05443668_101988	SAMN05443668_10884	CheY chemotaxis protein or a CheY-like REC (receiver) domain.	Two-component system, chemotaxis family, sensor kinase CheA.	0.992
SHM59652.1	SHN43436.1	SAMN05443668_101988	SAMN05443668_109168	CheY chemotaxis protein or a CheY-like REC (receiver) domain.	PAS domain S-box-containing protein.	0.999
SHM59652.1	SHN45358.1	SAMN05443668_101988	SAMN05443668_1123	CheY chemotaxis protein or a CheY-like REC (receiver) domain.	Two-component system, chemotaxis family, sensor kinase CheA.	0.992
SHM59652.1	SHN45372.1	SAMN05443668_101988	SAMN05443668_11210	CheY chemotaxis protein or a CheY-like REC (receiver) domain.	Purine-binding chemotaxis protein CheW.	0.983
SHM59652.1	SHN46215.1	SAMN05443668_101988	SAMN05443668_11448	CheY chemotaxis protein or a CheY-like REC (receiver) domain.	Methyl-accepting chemotaxis protein (MCP) signalling domain-containing protein.	0.974
SHM59652.1	SHN46759.1	SAMN05443668_101988	SAMN05443668_117142	CheY chemotaxis protein or a CheY-like REC (receiver) domain.	PAS domain S-box-containing protein.	0.999
SHM59652.1	SHN47482.1	SAMN05443668_101988	SAMN05443668_12440	CheY chemotaxis protein or a CheY-like REC (receiver) domain.	PAS domain S-box-containing protein.	0.999
SHM59652.1	SHN75054.1	SAMN05443668_101988	SAMN05443668_107207	CheY chemotaxis protein or a CheY-like REC (receiver) domain.	Signal transduction histidine kinase.	0.999
SHM72111.1	SHM59652.1	SAMN05443668_1011334	SAMN05443668_101988	PAS domain S-box-containing protein.	CheY chemotaxis protein or a CheY-like REC (receiver) domain.	0.999
SHM72111.1	SHN42111.1	SAMN05443668_1011334	SAMN05443668_10883	PAS domain S-box-containing protein.	Purine-binding chemotaxis protein CheW.	0.986
SHM72111.1	SHN42114.1	SAMN05443668_1011334	SAMN05443668_10884	PAS domain S-box-containing protein.	Two-component system, chemotaxis family, sensor kinase CheA.	0.997
SHM72111.1	SHN43436.1	SAMN05443668_1011334	SAMN05443668_109168	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.999
SHM72111.1	SHN45358.1	SAMN05443668_1011334	SAMN05443668_1123	PAS domain S-box-containing protein.	Two-component system, chemotaxis family, sensor kinase CheA.	0.997
SHM72111.1	SHN45372.1	SAMN05443668_1011334	SAMN05443668_11210	PAS domain S-box-containing protein.	Purine-binding chemotaxis protein CheW.	0.984
SHM72111.1	SHN46215.1	SAMN05443668_1011334	SAMN05443668_11448	PAS domain S-box-containing protein.	Methyl-accepting chemotaxis protein (MCP) signalling domain-containing protein.	0.973
SHM72111.1	SHN46759.1	SAMN05443668_1011334	SAMN05443668_117142	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.999
SHM72111.1	SHN47482.1	SAMN05443668_1011334	SAMN05443668_12440	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.999
SHM72111.1	SHN75054.1	SAMN05443668_1011334	SAMN05443668_107207	PAS domain S-box-containing protein.	Signal transduction histidine kinase.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.828

expected number of edges:

11

PPI enrichment p-value:

3.05e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

11 of 641

0.85

0.89

7.45e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015099

Nickel cation transmembrane transporter activity

10 of 36

2.06

6.23

3.69e-17

GO:0015413

ABC-type nickel transporter activity

2 of 2

2.61

1.41

0.0026

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

11 of 895

0.7

0.67

2.86e-06

GO:0016021

Integral component of membrane

9 of 1090

0.53

0.41

0.0035

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6402

Nickel cation transmembrane transporter activity, and Peptide transport

10 of 47

1.94

5.58

1.01e-16

CL:6399

Nickel cation transmembrane transporter activity, and Peptide transport

11 of 65

1.84

5.23

1.49e-17

CL:6485

ABC-type nickel transporter activity, and Oligopeptide transport permease C-like, N-terminal domain

5 of 5

2.61

4.76

6.98e-10

CL:6403

Nickel cation transmembrane transporter activity, and Peptide transport

5 of 41

1.7

2.25

3.34e-06

CL:6404

Nickel cation transmembrane transporter activity, and Peptide transport

3 of 30

1.61

1.1

0.0045

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

siw02024

Quorum sensing

5 of 160

1.11

0.87

0.0026

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

9 of 90

1.61

3.41

1.15e-12

MAP-9635486

Infection with Mycobacterium tuberculosis

9 of 151

1.39

2.41

4.87e-11

MAP-5663205

Infectious disease

9 of 154

1.38

2.39

4.87e-11

MAP-1643685

Disease

9 of 158

1.37

2.35

4.87e-11

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

6 of 64

1.58

2.17

1.50e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

9 of 317

1.07

1.27

5.15e-07

KW-1003

Cell membrane

9 of 322

1.06

1.25

5.15e-07

KW-1133

Transmembrane helix

8 of 948

0.54

0.36

0.0195

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12911

N-terminal TM domain of oligopeptide transport permease C

5 of 11

2.27

3.65

3.98e-08

PF00528

Binding-protein-dependent transport system inner membrane component

8 of 96

1.53

2.57

5.85e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR025966

Oligopeptide transport permease C-like, N-terminal domain

6 of 11

2.35

4.49

7.69e-10

IPR035906

MetI-like superfamily

8 of 97

1.53

2.53

8.11e-09

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

8 of 97

1.53

2.53

8.11e-09

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