SHN46555.1 protein (Cryptosporangium aurantiacum)

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SHN46555.1

acyl-CoA dehydrogenase. (361 aa)

Predicted Functional Partners:

SHN18712.1

0.942

SHM58337.1

0.939

SHN16260.1

0.936

SHN46554.1

0.929

SHN17176.1

0.910

SHN48155.1

0.902

SHN39965.1

0.897

SHN43685.1

0.881

SHN40132.1

0.863

SHN43680.1

0.861

Your Current Organism:

Cryptosporangium aurantiacum

NCBI taxonomy Id: 134849
Other names: Actinoplanes aurantiacus, C. aurantiacum, DSM 46144, IFO 13967, IMET 9261, IMSNU 22120, JCM 3241, KCC A-0241, KCTC 9529, NBRC 13967, NCIMB 12649, NRRL B-16698, strain 71-C38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHM58337.1	SHN46555.1	SAMN05443668_101952	SAMN05443668_11691	Acyl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.939
SHN16260.1	SHN46555.1	SAMN05443668_103341	SAMN05443668_11691	Acyl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.936
SHN17176.1	SHN46555.1	SAMN05443668_103412	SAMN05443668_11691	Acyl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.910
SHN18712.1	SHN46555.1	SAMN05443668_103520	SAMN05443668_11691	Acyl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.942
SHN39965.1	SHN46555.1	SAMN05443668_106397	SAMN05443668_11691	Acyl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.897
SHN40132.1	SHN46555.1	SAMN05443668_106436	SAMN05443668_11691	Acyl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.863
SHN43680.1	SHN43685.1	SAMN05443668_109301	SAMN05443668_109303	Acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.597
SHN43680.1	SHN46555.1	SAMN05443668_109301	SAMN05443668_11691	Acyl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.861
SHN43685.1	SHN43680.1	SAMN05443668_109303	SAMN05443668_109301	Acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.597
SHN43685.1	SHN46555.1	SAMN05443668_109303	SAMN05443668_11691	Acyl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.881
SHN46554.1	SHN46555.1	SAMN05443668_11690	SAMN05443668_11691	Acyl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.929
SHN46555.1	SHM58337.1	SAMN05443668_11691	SAMN05443668_101952	acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.939
SHN46555.1	SHN16260.1	SAMN05443668_11691	SAMN05443668_103341	acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.936
SHN46555.1	SHN17176.1	SAMN05443668_11691	SAMN05443668_103412	acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.910
SHN46555.1	SHN18712.1	SAMN05443668_11691	SAMN05443668_103520	acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.942
SHN46555.1	SHN39965.1	SAMN05443668_11691	SAMN05443668_106397	acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.897
SHN46555.1	SHN40132.1	SAMN05443668_11691	SAMN05443668_106436	acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.863
SHN46555.1	SHN43680.1	SAMN05443668_11691	SAMN05443668_109301	acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.861
SHN46555.1	SHN43685.1	SAMN05443668_11691	SAMN05443668_109303	acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.881
SHN46555.1	SHN46554.1	SAMN05443668_11691	SAMN05443668_11690	acyl-CoA dehydrogenase.	Acyl-CoA dehydrogenase.	0.929

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.828

expected number of edges:

11

PPI enrichment p-value:

3.05e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

11 of 641

0.85

0.89

7.45e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015099

Nickel cation transmembrane transporter activity

10 of 36

2.06

6.23

3.69e-17

GO:0015413

ABC-type nickel transporter activity

2 of 2

2.61

1.41

0.0026

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

11 of 895

0.7

0.67

2.86e-06

GO:0016021

Integral component of membrane

9 of 1090

0.53

0.41

0.0035

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6402

Nickel cation transmembrane transporter activity, and Peptide transport

10 of 47

1.94

5.58

1.01e-16

CL:6399

Nickel cation transmembrane transporter activity, and Peptide transport

11 of 65

1.84

5.23

1.49e-17

CL:6485

ABC-type nickel transporter activity, and Oligopeptide transport permease C-like, N-terminal domain

5 of 5

2.61

4.76

6.98e-10

CL:6403

Nickel cation transmembrane transporter activity, and Peptide transport

5 of 41

1.7

2.25

3.34e-06

CL:6404

Nickel cation transmembrane transporter activity, and Peptide transport

3 of 30

1.61

1.1

0.0045

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

siw02024

Quorum sensing

5 of 160

1.11

0.87

0.0026

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

9 of 90

1.61

3.41

1.15e-12

MAP-9635486

Infection with Mycobacterium tuberculosis

9 of 151

1.39

2.41

4.87e-11

MAP-5663205

Infectious disease

9 of 154

1.38

2.39

4.87e-11

MAP-1643685

Disease

9 of 158

1.37

2.35

4.87e-11

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

6 of 64

1.58

2.17

1.50e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

9 of 317

1.07

1.27

5.15e-07

KW-1003

Cell membrane

9 of 322

1.06

1.25

5.15e-07

KW-1133

Transmembrane helix

8 of 948

0.54

0.36

0.0195

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12911

N-terminal TM domain of oligopeptide transport permease C

5 of 11

2.27

3.65

3.98e-08

PF00528

Binding-protein-dependent transport system inner membrane component

8 of 96

1.53

2.57

5.85e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR025966

Oligopeptide transport permease C-like, N-terminal domain

6 of 11

2.35

4.49

7.69e-10

IPR035906

MetI-like superfamily

8 of 97

1.53

2.53

8.11e-09

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

8 of 97

1.53

2.53

8.11e-09

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