KIC96257.1 protein (Flavihumibacter solisilvae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

KIC96257.1

ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)

Predicted Functional Partners:

KIC96256.1

0.795

KIC94249.1

0.548

KIC96255.1

0.507

KIC93406.1

0.463

KIC95423.1

0.457

KIC95860.1

0.413

KIC92851.1

0.404

Your Current Organism:

Flavihumibacter solisilvae

NCBI taxonomy Id: 1349421
Other names: F. solisilvae, Flavihumibacter solisilvae Lee et al. 2014 emend. Hahnke et al. 2016, Flavihumibacter sp. 3_3, JCM 19891, KACC 17917, strain 3-3, strain 3_3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIC92851.1	KIC96257.1	OI18_20755	OI18_00355	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.404
KIC93406.1	KIC96257.1	OI18_16640	OI18_00355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.463
KIC94249.1	KIC96257.1	OI18_12810	OI18_00355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.548
KIC95423.1	KIC96257.1	OI18_05890	OI18_00355	DoxX-like family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.457
KIC95860.1	KIC96257.1	OI18_04330	OI18_00355	Glycoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.413
KIC96255.1	KIC96256.1	OI18_00345	OI18_00350	3-demethylubiquinone-9 3-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ArsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.492
KIC96255.1	KIC96257.1	OI18_00345	OI18_00355	3-demethylubiquinone-9 3-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.507
KIC96256.1	KIC96255.1	OI18_00350	OI18_00345	ArsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-demethylubiquinone-9 3-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.492
KIC96256.1	KIC96257.1	OI18_00350	OI18_00355	ArsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.795
KIC96257.1	KIC92851.1	OI18_00355	OI18_20755	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.404
KIC96257.1	KIC93406.1	OI18_00355	OI18_16640	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.463
KIC96257.1	KIC94249.1	OI18_00355	OI18_12810	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.548
KIC96257.1	KIC95423.1	OI18_00355	OI18_05890	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DoxX-like family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.457
KIC96257.1	KIC95860.1	OI18_00355	OI18_04330	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glycoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.413
KIC96257.1	KIC96255.1	OI18_00355	OI18_00345	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-demethylubiquinone-9 3-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.507
KIC96257.1	KIC96256.1	OI18_00355	OI18_00350	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ArsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.795

Network Stats

number of nodes:

9

number of edges:

8

average node degree:

1.78

avg. local clustering coefficient:

0.889

expected number of edges:

8

PPI enrichment p-value:

0.55

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006281

DNA repair

7 of 49

1.75

3.18

7.26e-09

GO:0090304

Nucleic acid metabolic process

8 of 304

1.02

1.1

5.62e-06

GO:0006284

Base-excision repair

2 of 8

2.0

0.98

0.0174

GO:0006304

DNA modification

2 of 11

1.86

0.85

0.0286

GO:0043170

Macromolecule metabolic process

9 of 703

0.71

0.62

7.74e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008853

Exodeoxyribonuclease III activity

4 of 4

2.6

3.41

9.18e-07

GO:0004519

Endonuclease activity

4 of 26

1.79

2.08

3.89e-05

GO:0140097

Catalytic activity, acting on DNA

6 of 83

1.46

1.92

3.23e-06

GO:0003905

Alkylbase DNA N-glycosylase activity

2 of 3

2.42

1.48

0.0027

GO:0008270

Zinc ion binding

4 of 60

1.42

1.34

0.00056

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:682

Base excision repair, and methylated-DNA-[protein]-cysteine S-methyltransferase activity

7 of 13

2.33

5.86

1.51e-12

CL:684

AP endonuclease 1, and DNA glycosylase

4 of 7

2.36

3.15

1.63e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

woc03410

Base excision repair

5 of 15

2.12

3.65

4.34e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03372

Endonuclease/Exonuclease/phosphatase family

3 of 7

2.23

1.74

0.00076

PF02805

Metal binding domain of Ada

2 of 2

2.6

1.18

0.0097

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036691

Endonuclease/exonuclease/phosphatase superfamily

4 of 8

2.3

2.66

1.35e-05

IPR037493

Exodeoxyribonuclease III-like

3 of 3

2.6

2.19

0.00016

IPR004808

AP endonuclease 1

3 of 3

2.6

2.19

0.00016

IPR005135

Endonuclease/exonuclease/phosphatase

3 of 7

2.23

1.84

0.00049

IPR035451

Ada-like domain superfamily

2 of 2

2.6

1.17

0.0100

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00342

Helix_turn_helix, arabinose operon control protein

2 of 2

2.6

1.41

0.0038

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