close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dcuRResponse regulator receiver protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)    
Predicted Functional Partners:
dcuS_2
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
dcuS_1
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.998
AOM16707.1
Transcriptional antiterminator; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.769
AOM16315.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.682
walK
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.631
recG
ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily.
      
 0.597
AOM17141.1
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.590
frlR
GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.568
MleP
Citrate:sodium symporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.558
srrA_2
PhoB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.540
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.