Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
addBATP-dependent helicase; ATP-dependent DNA helicase; Belongs to the helicase family. AddB/RexB type 2 subfamily. (1175 aa)    
Predicted Functional Partners:
addA
DNA helicase UvrD; ATP-dependent DNA helicase.
 
 
 0.999
yybR
HxlR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.794
recF_1
Recombinase RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family.
      
 0.728
trmK
SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.651
recJ
Recombinase RecJ; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.615
sbcD
Exonuclease SbcD; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
  
  
 0.596
TopB
DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.552
ruvB
ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
      
 0.536
AOM15740.1
Nitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.528
AOM17176.1
RNA polymerase subunit sigma-70; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family.
  
     0.518
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
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