glnQ protein (Enterococcus faecium) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

glnQ

Amino acid ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)

Predicted Functional Partners:

GlnC

0.999

artQ

0.998

peb1A

0.996

yecS

0.962

AOM15889.1

0.950

AOM16838.1

0.949

ecsA_3

0.899

AOM17508.1

0.859

AOM15890.1

0.832

fliY

0.831

Your Current Organism:

Enterococcus faecium

NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOM15889.1	AOM15890.1	AL014_06315	AL014_06320	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial solute-binding protein 3 family.	0.999
AOM15889.1	AOM16838.1	AL014_06315	AL014_11425	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.659
AOM15889.1	artQ	AL014_06315	AL014_05605	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.484
AOM15889.1	fliY	AL014_06315	AL014_15050	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.945
AOM15889.1	glnQ	AL014_06315	AL014_05590	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.950
AOM15889.1	peb1A	AL014_06315	AL014_05595	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.928
AOM15889.1	yecS	AL014_06315	AL014_15040	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.556
AOM15890.1	AOM15889.1	AL014_06320	AL014_06315	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial solute-binding protein 3 family.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AOM15890.1	AOM16838.1	AL014_06320	AL014_11425	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial solute-binding protein 3 family.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.659
AOM15890.1	GlnC	AL014_06320	AL014_05600	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial solute-binding protein 3 family.	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
AOM15890.1	artQ	AL014_06320	AL014_05605	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial solute-binding protein 3 family.	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.970
AOM15890.1	glnQ	AL014_06320	AL014_05590	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial solute-binding protein 3 family.	Amino acid ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.832
AOM15890.1	yecS	AL014_06320	AL014_15040	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial solute-binding protein 3 family.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.983
AOM16838.1	AOM15889.1	AL014_11425	AL014_06315	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.659
AOM16838.1	AOM15890.1	AL014_11425	AL014_06320	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial solute-binding protein 3 family.	0.659
AOM16838.1	GlnC	AL014_11425	AL014_05600	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.447
AOM16838.1	artQ	AL014_11425	AL014_05605	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.665
AOM16838.1	fliY	AL014_11425	AL014_15050	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.465
AOM16838.1	glnQ	AL014_11425	AL014_05590	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amino acid ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.949
AOM16838.1	peb1A	AL014_11425	AL014_05595	Amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.502

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.777

expected number of edges:

11

PPI enrichment p-value:

2.54e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008616

Queuosine biosynthetic process

4 of 9

2.28

2.48

1.52e-05

GO:0006396

RNA processing

5 of 61

1.55

1.79

2.65e-05

GO:0008033

tRNA processing

4 of 37

1.67

1.69

0.00014

GO:0034654

Nucleobase-containing compound biosynthetic process

6 of 167

1.19

1.22

9.00e-05

GO:1901137

Carbohydrate derivative biosynthetic process

6 of 172

1.18

1.19

9.90e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140101

Catalytic activity, acting on a tRNA

4 of 57

1.48

0.99

0.0063

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1534

0.45

0.33

0.0142

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1459

Mixed, incl. Queuosine biosynthesis, and Ion transporter-like, CBS domain

5 of 21

2.01

2.73

1.62e-06

CL:1484

Queuosine biosynthesis, and Ribbon-helix-helix domain

3 of 5

2.41

1.98

0.00019

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0671

Queuosine biosynthesis

4 of 7

2.39

3.08

1.13e-06

KW-0819

tRNA processing

4 of 25

1.84

2.03

3.96e-05

KW-0963

Cytoplasm

5 of 252

0.93

0.62

0.0116

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About