close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UxuBDioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (548 aa)    
Predicted Functional Partners:
uxuA_1
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.
 
 0.997
uxaC
Glucuronate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.992
uxuA
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.
 
 0.989
ydfH_1
GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.965
ydfH_2
GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.741
mtlF_1
PTS mannitol transporter subunit IIA; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.649
mtlF
PTS mannitol transporter subunit IIA; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.649
uidB
Melibiose carrier protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.541
MtlA2
PTS sugar transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.532
mtlA_2
PTS mannitol transferase subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.532
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
Server load: medium (66%) [HD]