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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srlAPTS glucitol/sorbitol transporter subunit IIC; Catalyzes the phosphorylation of incoming sugar substrates along with their translocation across the cell membrane; the IIC domain forms the PTS system translocation channel and contains the specific substrate-binding site; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)    
Predicted Functional Partners:
GutN
PTS sorbitol transporter subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
SrlR
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.998
GutA
PTS sorbitol transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.996
fabG_3
Sorbitol-6-phosphate 2-dehydrogenase; Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
  0.996
licR_7
Transcription antiterminator BglG; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.986
srlB
PTS sorbitol transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.976
ptsH
Phosphocarrier protein HPr; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.908
licR_3
Transcription antiterminator BglG; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.576
Tal
Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.530
AOM15245.1
Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.474
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
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