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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ydeAGlutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)    
Predicted Functional Partners:
traL
Sodium ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.768
rpoD_1
RNA polymerase subunit sigma; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.606
AOM15138.1
GNAT family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.515
lexA_3
LexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
   
 
 0.495
AOM15071.1
ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.482
AOM14893.1
MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.465
AOM16098.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.449
AOM15968.1
Amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.443
entI
Immunity protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.410
AOM15841.1
MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.403
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
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