close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
arcAArginine deiminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)    
Predicted Functional Partners:
arcB
Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
 
 0.999
arcC
Carbamate kinase; Catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.991
arcD
Amino acid permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.939
aaxC
Amino acid permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.858
pheDC
Decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.752
AOM16608.1
Amino acid decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.717
tdc
Decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine. Plays a role in acid resistance since tyramine production via tyrosine decarboxylation appears to provide a cytosolic pH maintenance mechanism that helps the bacterium cope with acid stress such as that encountered in gastrointestinal tract (GIT) environments. Therefore, may contribute to the colonization of the human GIT by E.faecium (By similarity).
   
  
 0.641
Crp
Cyclic nucleotide-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.632
argR2
ArgR family transcriptional regulator; Regulates arginine biosynthesis genes.
     
 0.507
argR-2
ArgR family transcriptional regulator; Regulates arginine biosynthesis genes.
     
 0.495
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
Server load: medium (56%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.