Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
yeaZ_1Peptidase M22; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)    
Predicted Functional Partners:
gcp
tRNA threonylcarbamoyladenosine biosynthesis protein Gcp; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
 
 
 0.994
tsaE
ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.988
rimI
Alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18.
 
 
 0.963
rimI-2
Alanine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.962
birA
biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
 
    0.914
GalR2
LacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.751
galT
Galactose-1-phosphate uridylyltransferase; Catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.731
galE
UDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
       0.729
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.622
Pbp5
Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.563
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
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