STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhaCSodium:proton antiporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)    
Predicted Functional Partners:
pheDC
Decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.881
tdc
Decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine. Plays a role in acid resistance since tyramine production via tyrosine decarboxylation appears to provide a cytosolic pH maintenance mechanism that helps the bacterium cope with acid stress such as that encountered in gastrointestinal tract (GIT) environments. Therefore, may contribute to the colonization of the human GIT by E.faecium (By similarity).
 
   
 0.806
tyrS1
tyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
     
 0.805
hmpT
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.657
thiD2
Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.536
ArcT
Aminotransferase; Associated with arginine deiminase pathway genes; probably functions in arginine catabolism; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.491
napA
Sodium:proton antiporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
      
 0.483
metB
Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.456
TopB
DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.412
arcA
Arginine deiminase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.402
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.