close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mazFPemK family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (113 aa)    
Predicted Functional Partners:
AOM16528.1
AbrB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.944
ndoA
PemK family transcriptional regulator; Toxic component of a type II toxin-antitoxin (TA) system.
  
   
 0.841
relE
Addiction module toxin RelE; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.795
gyrB
DNA gyrase subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily.
      
 0.505
lexA_3
LexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
      
 0.483
AOM14896.1
Addiction module protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.478
AOM16804.1
Addiction module protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.465
tuf
Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
   
  
 0.456
yybR
HxlR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.436
ytcD
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.436
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.