Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AOM16683.1Amino acid permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)    
Predicted Functional Partners:
AOM16769.1
acyl-CoA thioester hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.805
PotB
Spermidine/putrescine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.804
AOM16684.1
Amino acid permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.782
mleA_1
Malate dehydrogenase; Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.631
cwlC
Cell wall hydrolase; Probably involved in cell-wall metabolism. Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.
      
 0.631
spxA
ArsR family transcriptional regulator; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily.
      
 0.599
spxA_1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family.
      
 0.597
AOM16682.1
ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.511
tdc
Decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine. Plays a role in acid resistance since tyramine production via tyrosine decarboxylation appears to provide a cytosolic pH maintenance mechanism that helps the bacterium cope with acid stress such as that encountered in gastrointestinal tract (GIT) environments. Therefore, may contribute to the colonization of the human GIT by E.faecium (By similarity).
     
 0.412
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
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