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The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UspAUniversal stress protein UspA; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)    
Predicted Functional Partners:
pepA
Glutamyl aminopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.801
PheT
tRNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
       0.800
AOM16760.1
Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.765
AOM16762.1
Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.582
MntH
Manganese transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.494
trxA
Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thioredoxin family.
   
 
 0.476
cspA
Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.460
raiA
Fis family transcriptional regulator; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
  
  
 0.458
Ada
Cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
  
    0.441
CspC
Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.440
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
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