| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bmr3_2 | frmB_2 | AL014_13735 | AL014_13740 | Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tributyrin esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.839 |
| bmr3_2 | metK | AL014_13735 | AL014_13730 | Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.824 |
| coaC | metK | AL014_08895 | AL014_13730 | Decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine; Derived by automated computational analysis using gene prediction method: Protein Homology. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.793 |
| frmB_2 | bmr3_2 | AL014_13740 | AL014_13735 | Tributyrin esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.839 |
| frmB_2 | metK | AL014_13740 | AL014_13730 | Tributyrin esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.771 |
| glsA | metK | AL014_06495 | AL014_13730 | Glutaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaminase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.827 |
| glsA | purF | AL014_06495 | AL014_05225 | Glutaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaminase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.903 |
| glyA | guaA | AL014_14985 | AL014_12010 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.602 |
| glyA | metK | AL014_14985 | AL014_13730 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.708 |
| glyA | prpA | AL014_14985 | AL014_06395 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.570 |
| glyA | purF | AL014_14985 | AL014_05225 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.747 |
| guaA | glyA | AL014_12010 | AL014_14985 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.602 |
| guaA | metK | AL014_12010 | AL014_13730 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.783 |
| guaA | purF | AL014_12010 | AL014_05225 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.823 |
| metE | metK | AL014_08790 | AL014_13730 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.967 |
| metE | msrC | AL014_08790 | AL014_07875 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. | GAF domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.900 |
| metE | prpA | AL014_08790 | AL014_06395 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.781 |
| metK | bmr3_2 | AL014_13730 | AL014_13735 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.824 |
| metK | coaC | AL014_13730 | AL014_08895 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.793 |
| metK | frmB_2 | AL014_13730 | AL014_13740 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Tributyrin esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.771 |
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