mecA protein (Enterococcus faecium) - STRING interaction network

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Score

mecA

Competence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. (217 aa)

Predicted Functional Partners:

CoiA

0.887

Pbp2A

0.886

ampC

0.769

pepF

0.742

AOM17373.1

0.719

rpoE

0.718

ClpC

0.714

AOM17354.1

0.706

Pbp2B

0.656

ecsB_2

0.652

Your Current Organism:

Enterococcus faecium

NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOM17354.1	AOM17373.1	AL014_14375	AL014_14470	GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.567
AOM17354.1	mecA	AL014_14375	AL014_14355	GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Competence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.	0.706
AOM17354.1	rpoE	AL014_14375	AL014_02165	GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-directed RNA polymerase subunit delta; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family.	0.472
AOM17373.1	AOM17354.1	AL014_14470	AL014_14375	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.567
AOM17373.1	mecA	AL014_14470	AL014_14355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Competence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.	0.719
AOM17373.1	rpoE	AL014_14470	AL014_02165	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-directed RNA polymerase subunit delta; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family.	0.629
ClpC	mecA	AL014_12485	AL014_14355	Clp protease ClpX; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpA/ClpB family.	Competence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.	0.714
CoiA	ecsB_2	AL014_14360	AL014_14170	Competence protein CoiA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.455
CoiA	mecA	AL014_14360	AL014_14355	Competence protein CoiA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Competence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.	0.887
CoiA	pepF	AL014_14360	AL014_14365	Competence protein CoiA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptidase PepB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.804
Pbp2A	Pbp2B	AL014_14005	AL014_04065	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cell division protein FtsI; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
Pbp2A	mecA	AL014_14005	AL014_14355	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Competence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.	0.886
Pbp2B	Pbp2A	AL014_04065	AL014_14005	Cell division protein FtsI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
Pbp2B	mecA	AL014_04065	AL014_14355	Cell division protein FtsI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Competence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.	0.656
Pbp2B	rpoE	AL014_04065	AL014_02165	Cell division protein FtsI; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-directed RNA polymerase subunit delta; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family.	0.456
ampC	mecA	AL014_14865	AL014_14355	Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Competence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.	0.769
ecsB_2	CoiA	AL014_14170	AL014_14360	Multidrug ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Competence protein CoiA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.455
ecsB_2	mecA	AL014_14170	AL014_14355	Multidrug ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Competence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.	0.652
ecsB_2	rpoE	AL014_14170	AL014_02165	Multidrug ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-directed RNA polymerase subunit delta; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family.	0.666
mecA	AOM17354.1	AL014_14355	AL014_14375	Competence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.	GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.706

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