| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMG48388.1 | AMG48391.1 | AL523_00645 | AL523_00660 | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aromatic compound catabolic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.901 |
| AMG48388.1 | AMG51045.1 | AL523_00645 | AL523_15405 | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.954 |
| AMG48388.1 | aroC | AL523_00645 | AL523_13610 | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.909 |
| AMG48388.1 | hisC | AL523_00645 | AL523_08705 | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.821 |
| AMG48388.1 | menB | AL523_00645 | AL523_00655 | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 1,4-dihydroxy-2-naphthoyl-CoA synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). | 0.972 |
| AMG48388.1 | menC | AL523_00645 | AL523_00630 | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.943 |
| AMG48388.1 | menD | AL523_00645 | AL523_00640 | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. | 0.999 |
| AMG48388.1 | menE | AL523_00645 | AL523_00650 | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-succinylbenzoate-CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily. | 0.962 |
| AMG48388.1 | menH | AL523_00645 | AL523_00635 | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). | 0.989 |
| AMG48388.1 | trpE | AL523_00645 | AL523_15410 | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. | 0.882 |
| AMG48391.1 | AMG48388.1 | AL523_00660 | AL523_00645 | Aromatic compound catabolic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.901 |
| AMG48391.1 | menB | AL523_00660 | AL523_00655 | Aromatic compound catabolic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 1,4-dihydroxy-2-naphthoyl-CoA synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). | 0.994 |
| AMG48391.1 | menC | AL523_00660 | AL523_00630 | Aromatic compound catabolic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.799 |
| AMG48391.1 | menD | AL523_00660 | AL523_00640 | Aromatic compound catabolic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. | 0.937 |
| AMG48391.1 | menE | AL523_00660 | AL523_00650 | Aromatic compound catabolic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-succinylbenzoate-CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily. | 0.942 |
| AMG48391.1 | menH | AL523_00660 | AL523_00635 | Aromatic compound catabolic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). | 0.901 |
| AMG51045.1 | AMG48388.1 | AL523_15405 | AL523_00645 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.954 |
| AMG51045.1 | aroC | AL523_15405 | AL523_13610 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.954 |
| AMG51045.1 | hisC | AL523_15405 | AL523_08705 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.426 |
| AMG51045.1 | trpE | AL523_15405 | AL523_15410 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. | Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. | 0.999 |
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