| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMG49782.1 | AMG50960.1 | AL523_08370 | AL523_14935 | Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.852 |
| AMG49782.1 | AMG50961.1 | AL523_08370 | AL523_14940 | Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.826 |
| AMG49782.1 | AMG51453.1 | AL523_08370 | AL523_09435 | Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.613 |
| AMG49782.1 | thrB | AL523_08370 | AL523_14930 | Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.796 |
| AMG50314.1 | AMG50960.1 | AL523_11365 | AL523_14935 | Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.953 |
| AMG50314.1 | AMG50961.1 | AL523_11365 | AL523_14940 | Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; Derived by automated computational analysis using gene prediction method: Protein Homology. | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.529 |
| AMG50314.1 | AMG51453.1 | AL523_11365 | AL523_09435 | Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.612 |
| AMG50314.1 | ilvA | AL523_11365 | AL523_10270 | Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.912 |
| AMG50314.1 | ilvC | AL523_11365 | AL523_10265 | Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; Derived by automated computational analysis using gene prediction method: Protein Homology. | Acetolactate synthase catalytic subunit; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.708 |
| AMG50314.1 | thrB | AL523_11365 | AL523_14930 | Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; Derived by automated computational analysis using gene prediction method: Protein Homology. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.591 |
| AMG50960.1 | AMG49782.1 | AL523_14935 | AL523_08370 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. | 0.852 |
| AMG50960.1 | AMG50314.1 | AL523_14935 | AL523_11365 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.953 |
| AMG50960.1 | AMG50961.1 | AL523_14935 | AL523_14940 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.996 |
| AMG50960.1 | AMG50962.1 | AL523_14935 | AL523_14945 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | ArsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.854 |
| AMG50960.1 | AMG50963.1 | AL523_14935 | AL523_14950 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Phosphoglucomutase; Catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.754 |
| AMG50960.1 | AMG51453.1 | AL523_14935 | AL523_09435 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.730 |
| AMG50960.1 | ilvA | AL523_14935 | AL523_10270 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.953 |
| AMG50960.1 | ilvC | AL523_14935 | AL523_10265 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Acetolactate synthase catalytic subunit; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.766 |
| AMG50960.1 | serC | AL523_14935 | AL523_02005 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | 0.953 |
| AMG50960.1 | thrB | AL523_14935 | AL523_14930 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.999 |
STRING v12.5 is now available!
