BSLG_04575 protein (Batrachochytrium salamandrivorans)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

BSLG_04575

RING-type domain-containing protein. (286 aa)

Predicted Functional Partners:

KATNAL2

0.984

BSLG_06357

0.980

BSLG_06679

0.977

BSLG_01312

0.974

BSLG_06836

0.971

BSLG_01262

0.939

BSLG_06265

0.927

BSLG_02080

0.927

BSLG_06653

0.890

BSLG_06347

0.890

Your Current Organism:

Batrachochytrium salamandrivorans

NCBI taxonomy Id: 1357716
Other names: AMFP13/1, B. salamandrivorans, Batrachochytrium salamandrivorans Martel, Blooi, Bossuyt & Pasmans 2013, CBS 135744, Chytridiales sp. AM-2013, Chytridiomycota sp. AM-2013

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BSLG_01262	BSLG_01312	A0A1S8W5L2	A0A1S8W5E6	Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.594
BSLG_01262	BSLG_04575	A0A1S8W5L2	A0A1S8VTP2	Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	RING-type domain-containing protein.	0.939
BSLG_01262	BSLG_06347	A0A1S8W5L2	A0A1S8VM51	Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.403
BSLG_01262	BSLG_06357	A0A1S8W5L2	A0A1S8VLN6	Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.437
BSLG_01262	BSLG_06653	A0A1S8W5L2	A0A1S8VKS9	Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.403
BSLG_01262	BSLG_06679	A0A1S8W5L2	A0A1S8VKQ7	Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.478
BSLG_01312	BSLG_01262	A0A1S8W5E6	A0A1S8W5L2	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.594
BSLG_01312	BSLG_02080	A0A1S8W5E6	A0A1S8W2G1	Uncharacterized protein.	PRKCSH domain-containing protein.	0.975
BSLG_01312	BSLG_04575	A0A1S8W5E6	A0A1S8VTP2	Uncharacterized protein.	RING-type domain-containing protein.	0.974
BSLG_01312	BSLG_06265	A0A1S8W5E6	A0A1S8VM75	Uncharacterized protein.	PRKCSH domain-containing protein.	0.975
BSLG_01312	BSLG_06347	A0A1S8W5E6	A0A1S8VM51	Uncharacterized protein.	Uncharacterized protein.	0.459
BSLG_01312	BSLG_06357	A0A1S8W5E6	A0A1S8VLN6	Uncharacterized protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.991
BSLG_01312	BSLG_06679	A0A1S8W5E6	A0A1S8VKQ7	Uncharacterized protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.994
BSLG_01312	BSLG_06836	A0A1S8W5E6	A0A1S8VKU6	Uncharacterized protein.	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family.	0.990
BSLG_01312	KATNAL2	A0A1S8W5E6	A0A1S8W180	Uncharacterized protein.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.571
BSLG_02080	BSLG_01312	A0A1S8W2G1	A0A1S8W5E6	PRKCSH domain-containing protein.	Uncharacterized protein.	0.975
BSLG_02080	BSLG_04575	A0A1S8W2G1	A0A1S8VTP2	PRKCSH domain-containing protein.	RING-type domain-containing protein.	0.927
BSLG_02080	BSLG_06347	A0A1S8W2G1	A0A1S8VM51	PRKCSH domain-containing protein.	Uncharacterized protein.	0.894
BSLG_02080	BSLG_06357	A0A1S8W2G1	A0A1S8VLN6	PRKCSH domain-containing protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.976
BSLG_02080	BSLG_06653	A0A1S8W2G1	A0A1S8VKS9	PRKCSH domain-containing protein.	Uncharacterized protein.	0.894

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.888

expected number of edges:

11

PPI enrichment p-value:

7.7e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090114

COPII-coated vesicle budding

4 of 17

2.75

3.44

4.11e-07

GO:0030203

Glycosaminoglycan metabolic process

3 of 13

2.74

2.38

4.24e-05

GO:0090110

COPII-coated vesicle cargo loading

2 of 13

2.57

1.15

0.0078

GO:0006886

Intracellular protein transport

4 of 493

1.29

0.79

0.0142

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0102148

N-acetyl-beta-D-galactosaminidase activity

3 of 4

3.26

2.99

3.84e-06

GO:0004563

beta-N-acetylhexosaminidase activity

3 of 4

3.26

2.99

3.84e-06

GO:0004197

Cysteine-type endopeptidase activity

3 of 89

1.91

1.25

0.0034

GO:0005198

Structural molecule activity

4 of 497

1.29

0.77

0.0155

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030127

COPII vesicle coat

4 of 20

2.68

3.65

1.40e-07

GO:0031080

Nuclear pore outer ring

2 of 7

2.84

1.9

0.00034

GO:0005764

Lysosome

3 of 83

1.94

1.71

0.00034

GO:0070971

Endoplasmic reticulum exit site

2 of 22

2.34

1.44

0.0021

GO:0005615

Extracellular space

3 of 139

1.71

1.38

0.0012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23813

COPII-coated vesicle budding

4 of 17

2.75

3.41

4.57e-07

CL:38623

Peptidase C1A, and Peptidase family A1 domain

4 of 75

2.11

2.32

2.27e-05

CL:38637

Mixed, incl. Peptidase C1A, and Saposin-like

3 of 49

2.17

1.83

0.00029

CL:23833

COPII-coated vesicle budding

2 of 5

2.98

1.75

0.00068

CL:23818

Sec24-like, trunk domain, and Protein transport protein SEC31-like

2 of 5

2.98

1.75

0.00068

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00603

Glycosphingolipid biosynthesis - globo and isoglobo series

3 of 16

2.65

2.74

7.93e-06

map00604

Glycosphingolipid biosynthesis - ganglio series

3 of 21

2.54

2.71

8.27e-06

map00531

Glycosaminoglycan degradation

3 of 42

2.23

2.27

3.85e-05

map00511

Other glycan degradation

3 of 43

2.22

2.27

3.85e-05

map00513

Various types of N-glycan biosynthesis

3 of 58

2.09

2.13

5.83e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2024101

CS/DS degradation

3 of 4

3.26

3.21

1.53e-06

MAP-2160916

Hyaluronan uptake and degradation

3 of 5

3.16

3.2

1.53e-06

MAP-2142845

Hyaluronan metabolism

3 of 6

3.08

3.2

1.53e-06

MAP-1793185

Chondroitin sulfate/dermatan sulfate metabolism

3 of 13

2.74

2.82

6.12e-06

MAP-2022857

Keratan sulfate degradation

3 of 19

2.58

2.65

1.12e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1905379

beta-N-acetylhexosaminidase complex

2 of 3

3.2

1.5

0.0020

GOCC:0031080

Nuclear pore outer ring

2 of 8

2.78

1.29

0.0045

GOCC:0070971

Endoplasmic reticulum exit site

2 of 11

2.64

1.25

0.0052

GOCC:0030134

COPII-coated ER to Golgi transport vesicle

2 of 22

2.34

1.01

0.0137

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

4 of 214

1.65

1.51

0.00043

KW-0788

Thiol protease

2 of 46

2.02

0.84

0.0266

KW-0378

Hydrolase

5 of 1524

0.9

0.53

0.0266

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00728

Glycosyl hydrolase family 20, catalytic domain

3 of 4

3.26

3.0

3.75e-06

PF14845

Beta-acetyl hexosaminidase like

2 of 3

3.2

1.55

0.0016

PF12931

Sec23-binding domain of Sec16

2 of 4

3.08

1.55

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR025705

Beta-hexosaminidase

3 of 4

3.26

2.74

1.10e-05

IPR015883

Glycoside hydrolase family 20, catalytic domain

3 of 4

3.26

2.74

1.10e-05

IPR040251

Protein transport protein SEC31-like

2 of 2

3.38

1.59

0.0014

IPR013201

Cathepsin propeptide inhibitor domain (I29)

3 of 39

2.27

1.55

0.0012

IPR037363

Sec13/Seh1 family

2 of 3

3.2

1.51

0.0019

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00848

Cathepsin propeptide inhibitor domain (I29)

3 of 39

2.27

1.85

0.00030

SM00320

WD40 repeats

4 of 236

1.61

1.45

0.00051

SM00645

Papain family cysteine protease

2 of 34

2.15

0.96

0.0161

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