Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CRKCRK proto-oncogene, adaptor protein. (297 aa)    
Predicted Functional Partners:
RAPGEF1
Rap guanine nucleotide exchange factor 1.
    
 0.995
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.993
CBL
Cbl proto-oncogene.
    
 0.992
EGFR
Receptor protein-tyrosine kinase.
    
 0.990
ENSMODP00000059954
Uncharacterized protein.
    
 0.976
PDGFRA
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
    
 0.971
PTK2
Uncharacterized protein.
    
 0.971
ENSMODP00000059161
FERM domain-containing protein.
    
 0.971
ABL2
Tyrosine-protein kinase.
    
 0.969
ABL1
Tyrosine-protein kinase.
    
 0.969
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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